hrp0089p2-p025 | Adrenals and HPA Axis P2 | ESPE2018

Very High Dehydroepiandrosterone Sulfate (DHEAS) in Serum of an Overweight Female Adolescent without a Tumor

Iliev Daniel , Braun Regina , Sanchez-Guijo Alberto , Wudy Stefan , Heckmann Doreen , Bruchelt Gernot , Rosner Anika , Grosser Gary , Geyer Joachim , Binder Gerhard

Here, we report on a female adolescent with overweight and a very high DHEAS serum level. The hypothesis that the origin of DHEAS excess was the presence of either an ovarian or a suprarenal DHEAS-producing tumor was not confirmed. Sonographic and MRT investigations did not support its presence. In addition, effective dexamethasone suppression of DHEA and DHEAS excluded this diagnosis. Steroid sulfatase (STS) hydrolyses alkyl and aryl steroid sulfates to their unconjugated for...